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NFL: DEC 22 Titans at Colts

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The Perfect 12-Team PPR Fantasy Football Draft Strategy: Round-by-Round

Creating the perfect round-by-round fantasy football draft strategy for a 12-team league in the 2025 NFL season depends on your scoring format (PPR, half-PPR, or standard), roster settings, and draft position.

But assuming full PPR, a 1QB, 2RB, 2WR, 1TE, 1FLEX, D/ST, K, 7 bench format, here’s a general round-by-round blueprint to dominate your draft.

But first a few draft tips:

  • Don’t draft based on last year’s finish. Watch preseason usage.

  • Use tiers. Don’t blindly follow rankings.

  • Monitor training camp injuries and rookie usage.

  • Use value-based drafting: always compare ADP vs. ceiling.

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1. General Principles (2025)

NFL: DEC 01 Chargers at Falcons Source:Getty

 

  • RBs are deeper than recent years, but elite pass-catching backs are still gold.

  • WRs are king in PPR – target high-target share and route runners.

  • Late-round QBs and TEs are still viable unless elite value falls.

  • Don’t draft a defense or kicker early. Stream weekly.

  • Watch the NFL preseason — avoid outdated rankings.

2. Rounds 1–2: Lock in a Stud WR or Elite RB

NFC Wild Card Playoffs: Minnesota Vikings v Los Angeles Rams Source:Getty

 

  • Prioritize WR-WR or WR-RB starts.

  • Top Targets:

    • WR: Justin Jefferson, CeeDee Lamb, Tyreek Hill, Ja’Marr Chase, Amon-Ra St. Brown

    • RB: Christian McCaffrey, Bijan Robinson, Breece Hall, Jahmyr Gibbs

Avoid reaching for QB or TE unless Travis Kelce falls to Round 2.

3. Rounds 3–4: Anchor Your Starting Lineup

AFC Divisional Playoffs: Baltimore Ravens v Buffalo Bills Source:Getty

 

  • Secure a top 15 RB or WR and consider a flex option.

  • Great time to grab RB2 or strong WR2.

  • Value picks:

    • WR: Chris Olave, Tee Higgins, Brandon Aiyuk, Drake London

    • RB: Rachaad White, James Cook, Kenneth Walker, Travis Etienne

    • TE (value): Sam LaPorta (late Round 3/early 4)

If QB1s like Jalen Hurts or Josh Allen fall to Round 4, consider it.

4. Rounds 5–6: Fill FLEX + Consider QB/TE

Tennessee Titans v Indianapolis Colts Source:Getty

 

  • Focus on upside WRs/RBs with breakout potential.

  • Look for:

    • WR: Zay Flowers, Christian Watson, Diontae Johnson, Ladd McConkey

    • RB: Zack Moss, Javonte Williams, D’Andre Swift

    • QB: Anthony Richardson, Dak Prescott, CJ Stroud

    • TE: Dalton Kincaid, Kyle Pitts

5. Rounds 7–8: High-Upside Depth

Philadelphia Eagles v Kansas City Chiefs Source:Getty

 

  • Target breakout candidates and players in good offenses.

  • Potential gems:

    • WR: George Pickens, Rashee Rice, Jahan Dotson, Elijah Moore

    • RB: Tyjae Spears, Kendre Miller, Jaylen Warren

    • QB (late-round): Brock Purdy, Tua Tagovailoa

6. Rounds 9–10: Round Out Bench + Grab Your QB/TE If Needed

Cincinnati Bengals v Pittsburgh Steelers Source:Getty

 

  • Take your QB1 or TE1 here if you’ve waited.

  • Great time for:

    • TE: Pat Freiermuth, Luke Musgrave

    • QB: Jared Goff, Geno Smith

    • Stash: Rookie RBs or WRs in strong systems

7. Rounds 11–14: Lottery Tickets & Sleepers

NFL: DEC 28 Broncos at Bengals Source:Getty

 

  • Take swings on rookies, backups, or handcuffs.

  • Ideas:

    • RB: Chase Brown, Roschon Johnson, Blake Corum

    • WR: rookies, injured stash players

8. Rounds 15–16: Defense & Kicker

Las Vegas Raiders v Tampa Bay Buccaneers Source:Getty

 

  • Stream these positions based on Week 1 matchups.

  • Look at:

    • D/ST: whoever plays a bad QB Week 1

    • K: High-powered offenses